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THE ORGANIC CHEMISTRY OF DRUG SYNTHESIS VOLUME 3

coldance   发表于 2005-11-26 23:27:20 | 显示全部楼层 | 阅读模式 | 跳转到指定楼层
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http://free5.ys168.com/?hwzgj5 the_organic_chemistry_of_drug_synthesis_v3.rar4 l0 @8 R1 Z6 `
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Preface9 `3 x' M1 O) h- D, E1 ^' L: ]8 n& |
Ihe first volume in this series represented the launching of a
. @; B7 w* V' g/ Q6 Z- H: v* itrial balloon on the part of the authors. In the first place,
0 |2 Y+ F$ _) K8 b3 V. O5 o  F8 [5 W8 Gwo were not entirely convinced that contemporary medicinal
( }# S/ T; Z6 t/ [. E; z2 }(hemistry could in fact be organized coherently on the basis of' q: _8 Q& M* o; k' u: E, Q
organic chemistry. If, however, one granted that this might be
$ |. F5 w; B" ]6 Q* @5 n& s: cdone, we were not at all certain that the exercise would engage
1 E6 k- z/ S+ i2 c; Y" O, \/ [) aIhe interest of others. That book's reception seemed to give
) e3 n3 D7 R1 K1 l3 U% U: I2 M" ]2 C- Lnri affirmative answer to each of these questions. The second
8 ^  G9 ]/ \5 `# svolume was prepared largely to fill gaps in the coverage and to
2 E! B3 i4 T; E: j8 wbring developments in all fields up to a common date - 1976.
. W2 f7 w) [' }$ c5 C+ hIn the process of preparing those volumes, we formed the habit
" o& Z; Z* e! x# i" u8 Hof scrutenizing the literature for new nonproprietary names as: |( D% P2 g1 w/ |0 [7 b  [8 w
mi indication of new chemical entities in or about to be in the
9 H& }2 h: I, ~4 E4 R. e« linic. It soon became apparent that the decreased number of' u/ Z3 b( _# h0 K7 a7 U7 H6 G
drugs being granted regulatory approval was not matched by a
& M$ G9 q; |; ]4 g% ^3 D1 wdecrease in the number of agents being given new generic
* e; b) Q! J; A% ]/ f7 XMrtmes, The flow of potential new drugs seemed fairly constant
; {6 b/ n5 u# z" x" }3 @# G( Hover the years. (For the benefit of the statistician, assignment
- r6 ]" R+ T3 L9 G, u6 L2 {of new USAN names is about 60 per year.) It was thus6 {; ^) w, r% ]- K3 j
ix
5 f2 o% h  y) B0 @x PREFACE$ a5 ~: r" |: t! h9 g( @9 ?
obvious that the subject matter first addressed in Volume 1 was* q+ R, G$ \6 p4 |
increasing at a fairly constant and impressive rate.
% w' B6 `5 i2 C# P6 JOnce we had provided the background data up to 1976, it% ?( d  D. d1 _' r% ^! d% f
seemed logical to keep the series current by adding discussion' C; o6 r+ V6 J& c
of newer agents. Reports of drugs for new indications as well
$ ?! ~2 ^$ }% z  m6 @) Ras the occurrence of brand-new structural types as drugs made
. h" _, A+ V, }it particularly important to update the existing volumes. The
+ l- u( F, L1 X! }five-year cycle for preparation of new volumes represents a, V4 H% _; n* i# U& o: a
compromise between timeliness and comprehensiveness. A shorter
) A5 W1 Q* v- A, d( |period would date earlier entries. This volume thus covers! k! M( Y# ~' ]* Z0 Z# s  @0 {6 T
compounds reported up to 1982.4 \7 \. t7 r# Z" p7 ]
As has been the practice in the earlier volumes, the only8 e  [$ u7 K. X) A/ W9 B: [" A
criterion for including a new therapeutic agent is its having" `! B! N! r: q* k/ |" Q
been assigned a United States nonproprietary name (USAN), a: S) Y2 G9 R2 I& ]& p. P
so-called generic name. Since the focus of this text is
- X$ D# u+ s; h- wchemistry, we have avoided in the main critical comments on% t6 K5 w) u* n9 i% P' @
pharmacology. The pharmacological activity or therapeutic' j  C( J/ o; O9 R+ e
utility described for the agents covered is that which was) s* q4 A2 }; i3 e$ a( C1 X
claimed when the USAN name was assigned.0 |: T; [& e# b! B% O5 x6 f2 R, A$ |% Z
The changes in chapter titles as well as changes in their6 k% A& t# ?8 A# S7 l& T' Q
relative sizes in going from volume to volume constitute an( q7 B* J4 F1 Y: T( e+ w: l8 B
interesting guide to directions of research in medicinal' _8 h" v: s) S8 ^+ ^" _
chemistry. The first two volumes, for example, contained4 D3 T/ |8 t4 a/ P! ~
extensive details on steroid drugs. This section has shrunk to
( t! z$ {, `8 `! `1 c! X$ jabout a third of its former size in this book. The section on
: ^9 U& f/ F% ~1 O, d3-lactam antibiotics, on the other hand, has undergone steady
* G" F6 K: s) I7 u: R1 ]" C7 ^growth from volume to volume: not only have the number of  t( x. q1 U+ b- ]) E( C( |: ^
entries multiplied but the syntheses have become more complex.% w" }9 e3 o+ `' w# J
PREFACE xi7 o+ W4 ]* X3 A5 w, t
This book, like its predecessors, is addressed to students4 s: Q( q2 k7 n% P, Q3 i9 v6 Y
<d the graduate level in organic and medicinal chemistry as1 Z! Y! ]/ O! ]4 e
well as to practitioners in the field. It is again assumed2 U; ^4 Z2 O- x
that the reader has a comfortable grasp of organic synthesis as+ A3 {6 `/ U# w+ Y" e
well as a basic grounding in biology.! Y4 [- ]( W2 ~9 U0 l! E5 h1 W
We are pleased to acknowledge the helpful assistance of
6 b; }; y7 k2 r' H'.overal individuals in preparing this volume. Particularly, we1 I6 C. j: g% @3 N3 w' ]
&laquo;ina grateful to Mrs. Janet Gill for preparing all of the; Z* C( U2 U1 Z* T/ w* [1 v2 F' P  U
illustrations and to Mrs. Violet Huseby for long hours and1 @* P4 C5 J$ }! K
(cireful attention to detail in preparing the final copy and( G2 z  S) }+ [0 n, B; a' i
several drafts.& _* R- O/ l$ W
Daniel Lednicer Dublin, Ohio
/ c6 s/ k& N" b" QI &laquo;*ster A. Mitscher Lawrence, Kansas2 ]( [5 S8 D- O1 C! \$ V8 S
January, 1984

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发表于 2005-11-26 23:27:20 | 显示全部楼层

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发表于 2005-11-26 23:28:10 | 显示全部楼层

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are you recommending a specialized book?
发表于 2005-11-26 23:37:07 | 显示全部楼层

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but it is so professional
发表于 2005-11-27 05:57:49 | 显示全部楼层

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hehe...
发表于 2005-12-2 15:39:41 | 显示全部楼层

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hehe!nice,anyway
发表于 2005-12-2 15:48:49 | 显示全部楼层

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This is the one I want!!!- w& `, ^  ?) b5 v( E- a
Thank you very very much!!!
发表于 2005-12-2 21:48:39 | 显示全部楼层

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