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THE ORGANIC CHEMISTRY OF DRUG SYNTHESIS VOLUME 3

coldance   发表于 2005-11-26 23:27:20 | 显示全部楼层 | 阅读模式 | 跳转到指定楼层
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http://free5.ys168.com/?hwzgj5 the_organic_chemistry_of_drug_synthesis_v3.rar
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mm: THE
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) v. |' u4 n7 c( B) C9 o) cPreface
9 z. \/ J5 W# J/ r. mIhe first volume in this series represented the launching of a6 r" A+ e! ]% z: {; O  j
trial balloon on the part of the authors. In the first place,' `. l% Z4 n( i; Q0 p3 R) r  J
wo were not entirely convinced that contemporary medicinal
4 R  A8 y" {: H- w- `+ X! m" P(hemistry could in fact be organized coherently on the basis of
4 f, k- I8 Y8 morganic chemistry. If, however, one granted that this might be/ }. }+ t+ j2 C
done, we were not at all certain that the exercise would engage
6 X* x$ V! J7 q2 Y" _4 WIhe interest of others. That book's reception seemed to give) C, H; N. A- u7 x3 C. S
nri affirmative answer to each of these questions. The second9 B0 G  w& n" W! {: {4 Y( |& O
volume was prepared largely to fill gaps in the coverage and to) T3 v8 c4 Y$ t  ?# h$ I
bring developments in all fields up to a common date - 1976.. u" n9 i' n; H; m# }7 X
In the process of preparing those volumes, we formed the habit
4 L- L) @4 ]# D: J' L, Nof scrutenizing the literature for new nonproprietary names as
/ D' {# t: {' Xmi indication of new chemical entities in or about to be in the2 U/ l9 G  a; B+ V4 E* ?
« linic. It soon became apparent that the decreased number of5 J. T! N6 O! v* |# ]$ f# F; O
drugs being granted regulatory approval was not matched by a
* k% f+ Z% t4 U* r/ B+ [decrease in the number of agents being given new generic
( |3 y: I2 S) M, _- f7 N6 {Mrtmes, The flow of potential new drugs seemed fairly constant
: A6 l) y3 K: {. r4 r7 N7 Q5 o7 iover the years. (For the benefit of the statistician, assignment2 a0 F8 v# D/ ]; [
of new USAN names is about 60 per year.) It was thus9 r- u7 b* p0 r. j& h# Y
ix4 G& q. }  ^7 m* ~7 @
x PREFACE( T2 W( }7 \1 g, p/ A
obvious that the subject matter first addressed in Volume 1 was+ H5 O* n7 {* u% J6 {
increasing at a fairly constant and impressive rate.
: R* J6 M$ f* V4 L& FOnce we had provided the background data up to 1976, it
0 f+ E0 F8 T, M- y( @seemed logical to keep the series current by adding discussion
# o2 y( N; z  p: Y& p4 }1 p  }: {of newer agents. Reports of drugs for new indications as well; [! d  z6 u& Y4 W6 D' v6 I
as the occurrence of brand-new structural types as drugs made& K8 ^' ]/ f8 n% G- G5 h
it particularly important to update the existing volumes. The
% [6 @) Y- l) e% }& V+ e2 Jfive-year cycle for preparation of new volumes represents a9 y) H( ^, ]6 J2 ~
compromise between timeliness and comprehensiveness. A shorter
3 n$ r& z6 q7 b& u5 aperiod would date earlier entries. This volume thus covers
! Q/ n1 Z/ _1 vcompounds reported up to 1982.
3 @% `# D- u6 f& v1 ~! }; f# VAs has been the practice in the earlier volumes, the only
7 [- |- t6 s6 ~* s9 ?2 K  x  b( k7 fcriterion for including a new therapeutic agent is its having
. J' L3 ^2 [% s3 A- Z) ebeen assigned a United States nonproprietary name (USAN), a
- g, a* e: y( ]! iso-called generic name. Since the focus of this text is1 Y6 c, N7 j/ z9 X$ K
chemistry, we have avoided in the main critical comments on
- n) K3 G$ _0 Y# ^" n! {: Epharmacology. The pharmacological activity or therapeutic
3 i3 d# T0 o% F* r7 Putility described for the agents covered is that which was
$ P3 Y8 k4 n1 J- F, L5 O8 R# N# oclaimed when the USAN name was assigned.
# m. y3 I% |4 c5 OThe changes in chapter titles as well as changes in their
* B2 n% c% C4 E0 M4 B6 a+ q" Frelative sizes in going from volume to volume constitute an4 V' N5 U2 e: B$ ]# V
interesting guide to directions of research in medicinal
/ Q( p" U& S6 F/ i. Mchemistry. The first two volumes, for example, contained
# Q+ K0 k) j; B9 Sextensive details on steroid drugs. This section has shrunk to- i, I& c$ U9 M4 z0 ?1 J
about a third of its former size in this book. The section on  U, ^  ]( C$ \- _  @! `
3-lactam antibiotics, on the other hand, has undergone steady; N- h- x5 D' @8 M: C# Z2 Z, r
growth from volume to volume: not only have the number of! F) t; d, d; h1 l. b) I& f
entries multiplied but the syntheses have become more complex.
! S6 J$ F. {/ x& x  A$ VPREFACE xi
! c6 A( i9 L$ n: Z- Z% n# o8 [& T" gThis book, like its predecessors, is addressed to students
( G7 k" v& d& n- ?1 V. |+ h( J3 F<d the graduate level in organic and medicinal chemistry as
. M* z* ?2 ]' D' {! Gwell as to practitioners in the field. It is again assumed
: ]# F8 R( R, K  Mthat the reader has a comfortable grasp of organic synthesis as
! W4 l; B: a: v6 pwell as a basic grounding in biology.
& G$ Z* K. D4 w" }3 d! }: DWe are pleased to acknowledge the helpful assistance of
  N, |/ k: O' G8 [5 \! E# C2 z# ]'.overal individuals in preparing this volume. Particularly, we
( K, f8 k# w8 p' y&laquo;ina grateful to Mrs. Janet Gill for preparing all of the0 R5 g$ l0 U2 f" z: e5 Y5 ^) H" h
illustrations and to Mrs. Violet Huseby for long hours and
9 K, f- _/ X, P$ d5 _+ ^(cireful attention to detail in preparing the final copy and8 Q6 H2 x2 x' Z
several drafts.  _1 r7 `9 @) g& R
Daniel Lednicer Dublin, Ohio' x! X0 t+ A$ I$ O, y, M
I &laquo;*ster A. Mitscher Lawrence, Kansas; }; `- B/ R3 y) a/ G, c
January, 1984

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发表于 2005-11-26 23:28:10 | 显示全部楼层

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are you recommending a specialized book?
发表于 2005-11-26 23:37:07 | 显示全部楼层

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but it is so professional
发表于 2005-11-27 05:57:49 | 显示全部楼层

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hehe...
发表于 2005-12-2 15:39:41 | 显示全部楼层

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hehe!nice,anyway
发表于 2005-12-2 15:48:49 | 显示全部楼层

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This is the one I want!!!
9 S/ a; B4 E8 q/ J: _6 SThank you very very much!!!
发表于 2005-12-2 21:48:39 | 显示全部楼层

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